ESPN's "Monday Night Football" matchup will have a major impact on both the AFC and NFC playoff pictures. Here's what to know ...

The Indianapolis Colts will look to snap a four-game losing streak when they battle the San Francisco 49ers on Monday Night ...

Phillip Rivers leads the Indianapolis Colts against Brock Purdy and the San Francisco 49ers tonight in this NFL Week 16 ...

The Colts played it safe through the air in Rivers’s return to action in Week 15. With his passes lacking a bit of zip, it’s ...

SportsLine's model simulated Indianapolis vs. San Francisco on 'MNF' 10,000 times and reveals its NFL picks today ...

Indianapolis Colts host the San Francisco 49ers for NFL Monday Night Football tonight in Week 16. MNF time, TV schedule, how ...

There are free trials for watching tonight's MNF game, and Sling will let you watch for $5. See all of your options for ...

Indianapolis Colts vs San Francisco 49ers picks, predictions, win probabilities for NFL Week 16 Monday Night Football game on ...

Brock Purdy threw five touchdown passes as the 49ers rolled to a 48-27 win over the Colts on Monday Night Football. Joe ...

San Francisco aims to improve playoff position while Indianapolis fights for postseason hopes with Philip Rivers at ...

San Francisco had touchdown drives of 69, 26 and 69 yards and a field-goal drive of 75 yards. Brock Purdy has three touchdown ...

Now back as the wily super-veteran, Rivers is pulling out all the tricks. And on this one, it worked to give the Colts an ...