Week 16 of the NFL season is closing out with a thriller between the San Francisco 49ers and the Indianapolis Colts. Unfortunately, a costly decision was made by the referees was made during the end of the first half.

The Colts are in danger of missing the postseason after a strong start to the 2025 regular season. Here are their playoff scenarios after Week 16.

The San Francisco 49ers have beaten the Indianapolis Colts 48-27 on “Monday Night Football” behind Brock Purdy ’s career-high five touchdown passes. Christian McCaffrey racked up 146 total scrimmage yards and caught two touchdowns, while George Kittle totaled seven receptions for 115 yards and a TD before leaving the game with an ankle injury.

The Indianapolis Colts host the San Francisco 49ers in NFL Week 16 action on 'Monday Night Football': Live score updates, highlights, where to watch.

The San Francisco 49ers still have a chance to claim the one seed in the NFC playoff bracket with a win in Week 16 over the Indianapolis Colts.

The consensus is that the Indianapolis Colts will fall to the San Francisco 49ers, and they must answer the doubt.

Photos from Cleveland Browns vs. Buffalo Bills in a 2025 NFL Week 16 game in Cleveland, where eyes will be on rookie Shedeur Sanders and Myles Garrett