MSK researchers are shedding new light on G-quadruplexes, a type of secondary DNA structure that can cause DNA replication to stall. The structures are a potential therapeutic target in cancer. Image ...

R-loops are structures that form when a strand of RNA (red) forms a stable structure with double-stranded DNA, causing one strand of the DNA to form a loop. R-loops are associated with gene ...

The puzzle seems impossible: take a three-billion-letter code and predict what happens if you swap a single letter. The code we’re talking about—the human genome—stores most of its instructions in ...

Many cancers harbor pro-proliferative mutations of the mitogen-activated protein kinase (MAPK) pathway. In BRAF-driven melanoma cells treated with BRAF inhibitors, subpopulations of cells escape ...

Researchers have discovered how cells activate a last-resort DNA repair system when severe damage strikes. When genetic ...

Here's a scenario: police take a blood sample from a crime scene. They compare the DNA to that of convicted criminals, but get no match. But they find someone with similar DNA, and that leads them to ...

Future data centers might do away with banks of hard drives and switch to a storage medium that nature has been using for billions of years – DNA. In a major step towards making that a reality, ...

While CRISPR is probably the most prominent gene-editing technology, there are others, some developed before and since. And people have been developing CRISPR variants to perform more specialized ...