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生物通
5月
冷冻电镜数据中基于密度与能量引导评估的小分子自动鉴定方法
冷冻电镜(cryo-EM)数据中的小分子鉴定是结构生物学与药物研发的关键难题。Muenks等研究人员开发了EMERALD-ID工具,通过结合物理力场与密度匹配度对小分子库进行精准筛选,在已公开数据中实现44%的准确鉴定率,并成功发现多个已发表结构中的错误鉴定案例 ...
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