本文推荐研究人员针对mRNA疫苗稳定性差、半衰期短的问题，开展了聚腺苷酸尾（poly(A) tail）结构优化的主题研究。通过设计含 ...

Human development starts from the fertilization of a fully matured oocyte. Oocyte maturation, fertilization, and early embryo development before zygotic activation is characterized by the absence of ...

As their name suggests, messenger RNAs (mRNAs) act as intermediary molecules in the transfer of genetic information from DNA to their translation into proteins. In eukaryotic organisms, including ...

Researchers have characterized how the essential mRNA poly(A) tails are synthesized in the budding yeast Saccharomyces cerevisiae. The study reveals several mechanisms controlling poly(A) tail lengths ...

Writing in Molecular Therapy Nucleic Acids, researchers hypothesized that using poly(A) tail mimetics to enhance mRNA expression from haploinsufficiency-associated genes could be a disease-modifying ...

Cells regulate RNA and protein abundance through a multi-layered process. Excitingly, peeling back one layer has revealed additional layers below, highlighting the complex nature of this process. For ...