San Francisco 49ers vs Carolina Panthers picks, predictions, odds, win probabilities for NFL Week 12 Monday Night Football game Nov. 24. Who will win?

Each pick has a confidence level of 1-10, with 10 being the most confident. For more information on the pick methodology, check out the Week 1 edition of this series. Keep in mind that since the idea here is to make high-percentage plays,

The Philadelphia Eagles come in as the NFC East champions, but the Buffalo Bills have work to do to retain their AFC East title when they host this NFL Week 17 matchup. The Eagles (10-5) hit a rough patch and went on a three-game losing skid because of an inconsistent offense but have bounced back to score 60 points in winning their past two games.

Let's update our NFL Power Rankings one more time ahead of Week 18. We also picked out lessons for all 32 teams in 2025.