Until recently, the maturation of the 3′-end of tRNA precursors in Bacteria has been assumed to follow the E. coli paradigm, in which a cleavage event downstream of tRNAs is followed by exonucleolytic ...

tRNA是生物遗传信息传递“中心法则”的重要参与者[1]。作为蛋白质翻译过程的解码器，tRNA负责将mRNA中的遗传信息精确地对应到蛋白质序列中。在tRNA合成过程中，前体tRNA (precursor tRNA, pre-tRNA) 需要经过一系列转录后加工和修饰，才能生成成熟的tRNA。其中一个 ...

多聚甘氨酸介导的FAM98B聚集破坏GGC重复体无序区域的tRNA加工 （导读 阿金）GGCC重复体扩增产生易于聚集的多聚甘氨酸蛋白质与神经退行性疾病相关。本研究表明多聚甘氨酸本身会形成多聚体，结合内源性富甘氨酸蛋白质，包括FAM98B，通过这个富甘氨酸内在无序区 ...

Researchers at the Department of Cell and Molecular Biology, Karolinska Institutet have made a major discovery in how human cells produce energy. Their study, published in the EMBO Journal, reveals ...

Ribonuclease P (RNase P) catalyzes the maturation of the 5' end of tRNA precursors. Typically these enzymes are ribonucleoproteins with a conserved RNA component responsible for catalysis. However, ...

The fruit fly lacks the tRNA nuclear export receptor Exportin-t, which only exports end-processed tRNAs to the cytoplasm to ensure the completion of the processing steps in the nucleus. The related ...

The ribosome, that protein-making machine, relies on other, smaller machines. For example, it works in concert with a mechanism that supplies amino-acid-carrying tRNAs, including tRNAs that require ...

The tRNA3 Leu gene from yeast contains an intervening sequence of 32 nucleotides not present in mature tRNA. This sequence is transcribed and subsequently removed during the maturation of the RNA. To ...

Researchers have identified a novel brain disorder that is neurodegenerative, but so early onset that it disrupts development, leading to disturbances in the formation and function of hindbrain ...

A team of researchers from Mass General Brigham led by Raghu Chivukla, MD, PhD released a new study linking protein aggregation to altered RNA processing in genetic forms of neurodegeneration.

I am a graduate student in Dr. Ashleigh Schaffer’s lab. Broadly, the lab seeks to understand molecular mechanisms of physiological and pathological neurodevelopment. In pursuing this goal, Dr.