Until recently, the maturation of the 3′-end of tRNA precursors in Bacteria has been assumed to follow the E. coli paradigm, in which a cleavage event downstream of tRNAs is followed by exonucleolytic ...

In cells transfer RNA (tRNA) translates genetic information from the encoding messenger RNA (mRNA) for protein synthesis. New results from ultrafast spectroscopy and in-depth theoretical calculations ...

In translation, aa-tRNA, EF-Tu and GTP form a ternary complex that binds to the ribosome, allowing codon-anticodon pairing in the 30S ribosomal subunit. Cognate codon recognition triggers fast GTP ...

In all living organisms, the biomolecule transfer RNA (tRNA) plays a fundamental role in protein production. tRNAs are generated from precursor molecules in several steps. The enzyme tRNA splicing ...

The structure of a key enzyme involved in protein production is revealed by cryo-electron microscopy (cryo-EM). Using cryo-EM, researchers at Goethe University (Frankfurt, Germany) shed light on ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, No. 27 (Jul. 3, 2007), pp. 11268-11273 (6 pages) Pyrrolysine (Pyl), the 22nd natural amino acid and ...

Archaeosine is synthesized via three steps in tRNA. ArcS, the second-step enzyme, transfers a lysine to preQ 0, which is introduced into tRNA by ArcTGT, the first-step enzyme. The resultant preQ 0-Lys ...

The genetic information on DNA is transcribed into messenger RNA (mRNA) and translated to the amino acid sequence by transfer RNA (tRNA) on the ribosome. Modified nucleosides within RNA are involved ...

Many viruses have genomes made of RNA. In human cells, messenger RNA (mRNA) molecules act as intermediates; cellular machinery copies a DNA sequence into mRNA so that it can then be translated into a ...