Who will win the Bucs vs. Panthers NFC South showdown? USA TODAY Sports provides the early predictions for every NFL Week 16 game.

The Rams and Seahawks are a delectable appetizer to what promises to be an incredible, and incredibly important, week of games.

Despite blowing a massive lead to Buffalo in Week 15, Drake Maye and the New England Patriots headline Trevor Knapp’s favorite moneyline picks for the upcoming slate.

For Week 16 NFL betting, SportsLine AI has evaluated the NFL odds and provided NFL betting picks for all 16 games. You can only see the AI predictions for the Week 16 NFL schedule here. After analyzing every game in Week 16, the AI says the Broncos (-3, 45.5), who have won 11 in a row, cover comfortably against the Jaguars .

Can Kyle Pitts follow up his career-best fantasy outing with another massive performance? Check out all of Michael Florio's TE starts and sits for Week 16 of the 2025 NFL season.

Head to NBC and Peacock to watch the Vikings vs Cowboys game. Live coverage begins with Football Night In America at 7 PM ET.

If those two results go the Broncos' way and the New England Patriots (11-3) and Buffalo Bills (10-4) also both lose, Denver could also clinch the No. 1 seed in the AFC, securing

Is Bucky Irving poised to bounce back from a disappointing outing? Which rookie running back should be in your lineup? Check out all of Michael Florio's RB starts and sits for Week 16 of the 2025 NFL fantasy season.

Via Zack Keefer of TheAthletic.com, the Week 15 game between the Colts and the Seahawks was the most-watched Colts game on CBS in Indianapolis in five years. And, of course, five years ago, Rivers was the team’s starting quarterback.