N ‐linked protein glycosylation is an essential and conserved process occurring in the endoplasmic reticulum (ER) of eukaryotic organisms. It is important for protein folding, oligomerization, quality ...

The development of the dentate gyrus is characterized by distinct phases establishing a durable stem‐cell pool required for postnatal and adult neurogenesis. Here, we report that Bcl11b/Ctip2, a zinc ...

Low‐voltage‐activated or T‐type Ca 2+ channels (T‐channels) are widely expressed, especially in the central nervous system where they contribute to pacemaker activities and are involved in the ...

To better understand the role of eIF4B phosphorylation in the control of translation initiation, we sought to identify the location of the phosphorylation sites within the eIF4B protein, and to ...

Activation of the cell surface CD95 receptor triggers a cascade of signaling events, including assembly of the death‐inducing signaling complex (DISC), that culminate in cellular apoptosis. In this ...

The secreted Mycobacterium tuberculosis complex proteins CFP‐10 and ESAT‐6 have recently been shown to play an essential role in tuberculosis pathogenesis. We have determined the solution structure of ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. A robust proteomic workflow quantifies more ...

The seven transmembrane domain G‐protein‐coupled receptors (GPCRs) constitute the largest membrane receptor family, and, owing to their crucial role in cell‐to‐cell communication and involvement in a ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Patients suffering from progranulin (PGRN) ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The viral M45 protein forms functional amyloid ...

G protein‐coupled receptors (GPCRs) play important roles in cellular communication. Upon agonist stimulation, GPCRs interact with heterotrimeric G proteins, which, in turn, activate a variety of ...