本研究在体证实了MSA中存在胆碱能通路特异性损伤，尤其PPN-丘脑通路作为运动调控关键枢纽，其损伤程度与疾病严重度密切关联。该发现不仅深化了对MSA病理机制的理解，也为未来开发胆碱能通路靶向治疗策略提供了影像学依据。团队下一步将推进多中心纵向研究，验 ...

Now, I’m also experiencing more consistent, significant autonomic dysfunction, with a myriad of other symptoms. In May 2024, ...

Tiziana Life Sciences (TLSA) announces the submission of its seventh annual Development Safety Update Report to the U.S. Food ...

Longtime Texas high school football coach Mike Robinson has died, DeSoto coach Claude Mathis confirmed to The Dallas Morning ...

MSA作为一种进展性神经退行性疾病，其病理核心为α-突触核蛋白在少突胶质细胞中异常沉积形成的胶质胞质包涵体。既往尸检研究提示脑干脚桥核（PPN）和基底前脑Meynert核（NBM）的胆碱能神经元显著丢失，但对其投射通路的在体评估及临床关联仍缺乏系统研究。 团队纳入103例MSA患者与44名健康对照者，通过多模态磁共振数据重建三条关键胆碱能通路：NBM-内侧皮层通路（经扣带回）、NBM-外侧皮层通路 ...

Lipoic acid offers no improvements in walking speed or other outcomes in patients with progressive multiple sclerosis ...

Tiziana reports excellent safety profile with intranasal foralumab after 37.4 patient-years cumulative exposureFDA denial of Sanofi’s tolebrutinib for nrSPMS shows need for safe therapy BOSTON, Dec.

As of Friday, December 26, Alterity Therapeutics Limited’s ATHE share price has dipped by 6.30%, which has investors questioning if this is right time to buy.

Detailed price information for Theravance Bio Ord (TBPH-Q) from The Globe and Mail including charting and trades.

The over‐the‐counter supplement lipoic acid may have a small beneficial effect in slowing the loss of gray matter in the brains of people with progressive forms of multiple sclerosis, according to new ...

The NASDAQ Biotechnology Index (INDEXNASDAQ:NBI) is trading at three year highs despite market volatility, responding to ...