Two more wins to the 1 seed. Brock Purdy threw a career-high five touchdown passes as the Niners' offense could not be ...

Brock Purdy replied in kind after Philip Rivers opened the scoring with a TD pass against the 49ers. Purdy responded with 2!

Brock Purdy threw a career-high five touchdown passes, two to running back Christian McCaffrey, and the San Francisco 49ers ...

Something Purdy had in common with 44-year-old Philip Rivers on Monday — mental sharpness, which came in handy in a big ...

Brock Purdy opened the second half with his fourth touchdown of the night. The 49ers extended their lead to 31-17 with 10:58 ...

Brock Purdy lit up MNF for the 49ers against the Colts, throwing five touchdown passes and making history with a mark not ...

Brock Purdy threw a career-high five touchdown passes and Dee Winters returned an interception 74 yards for a score to lead ...

The San Francisco 49ers may not be playing defense at the level they've played in the past as they approach the postseason, ...

The Week 16 edition of "Monday Night Football" between the Indianapolis Colts (8-7) and the San Francisco 49ers (11-4) will ...

This was Purdy at his dart-throwing best, completing 25 of 34 passes for 295 yards and five touchdowns, the first time any ...

Brock Purdy dominates MNF vs the Colts, with each touchdown reinforcing a historic trend of double-digit wins.

The Indianapolis Colts lose to the San Francisco 49ers in NFL Week 16 action on 'Monday Night Football': Score updates, ...