San Francisco already clinched a playoff berth but finds itself in the thick of the NFC West and wild card races.

Brock Purdy was a vastly different quarterback on Monday night against the Colts compared to his prior Monday Night Football ...

The Buffalo Bills, Jacksonville Jaguars and Los Angeles Chargers qualified for the AFC playoffs with the Indianapolis Colts’ ...

The Jacksonville Jaguars will have a chance at winning the Super Bowl this season after earning a playoff spot following ...

With 7:14 to go in the opening quarter, Colts returner Ameer Abdullah received the kickoff and cut inside as Niners safety Ji'Ayir Brown remained under control and redirected to Abdullah. Brown ...

As Monday Night Football between the San Francisco 49ers and Indianapolis Colts kicks off, the New England Patriots got some ...

The San Francisco 49ers have beaten the Indianapolis Colts 48-27 on “Monday Night Football” behind Brock Purdy ’s career-high five touchdown passes. Christian McCaffrey racked up 146 total scrimmage ...

The Colts' loss clinched playoff spots for the Bills and Chargers. The 49ers had already clinched their spot in the NFC, and ...

The Week 16 edition of "Monday Night Football" between the Indianapolis Colts (8-7) and the San Francisco 49ers (11-4) will ...

Philip Rivers starts again when he takes on the ferocious 49ers on "Monday Night Football." Here's score, highlights, stats and more for Colts-49ers.

The Indianapolis Colts lose to the San Francisco 49ers in NFL Week 16 action on 'Monday Night Football': Score updates, highlights ...

The Buffalo Bills have punched their ticket to the playoffs when the 2025 NFL regular season ends in a few weeks. The Bills (11-4) beat the Cleveland Browns (3-11) in a 23-20 final on Sunday. The ...