CAG repeats can get longer over time as the HD gene is used, like the growing potholes and cracks in an old road. New ...

POINT-HD has begun dosing its first participants with the drug RG6496, marking an early but important step for a new selective huntingtin-lowering approach.

Studies in mice that model Huntington’s disease suggest that prebiotics – the food that feeds our gut bacteria – might ...

UniQure received FDA’s meeting minutes on AMT-130. While there were no new updates, the community’s response has been ...

By setting up both reactions side by side in a test tube, the team revealed a literal tug-of-war between two DNA-repair pathways acting on the same HTT repeat. Which side wins likely determines ...

Imagine a busy clothing factory. Proteins are like newly sewn shirts coming off the machines. They’re floppy, wrinkled, and can create a giant mess if they’re left unfolded. Normally, the cellular ...

Welcome back to the HDBuzz monthly research roundup! November was a busy month, with new developments in everything from gene therapy and stem cells to DNA repair, genetic modifiers, and protein ...

In plain language. Written by scientists. For the global HD community. A new study from Switzerland sheds light on how the CAG repeat number in the Huntington’s disease gene can grow or shrink inside ...

Piere studied Biology at Cayetano Heredia University in Lima (Peru), then obtained a PhD in Biophysics at UC Berkeley in the Bustamante Lab, specializing in molecular motors and single-molecule ...

In plain language. Written by scientists. For the global HD community. A new study from Switzerland sheds light on how the CAG repeat number in the Huntington’s disease gene can grow or shrink inside ...