Now, I’m also experiencing more consistent, significant autonomic dysfunction, with a myriad of other symptoms. In May 2024, ...

Tiziana Life Sciences (TLSA) announces the submission of its seventh annual Development Safety Update Report to the U.S. Food ...

本研究在体证实了MSA中存在胆碱能通路特异性损伤，尤其PPN-丘脑通路作为运动调控关键枢纽，其损伤程度与疾病严重度密切关联。该发现不仅深化了对MSA病理机制的理解，也为未来开发胆碱能通路靶向治疗策略提供了影像学依据。团队下一步将推进多中心纵向研究，验 ...

MSA作为一种进展性神经退行性疾病，其病理核心为α-突触核蛋白在少突胶质细胞中异常沉积形成的胶质胞质包涵体。既往尸检研究提示脑干脚桥核（PPN）和基底前脑Meynert核（NBM）的胆碱能神经元显著丢失，但对其投射通路的在体评估及临床关联仍缺乏系统研究。 团队纳入103例MSA患者与44名健康对照者，通过多模态磁共振数据重建三条关键胆碱能通路：NBM-内侧皮层通路（经扣带回）、NBM-外侧皮层通路 ...

Tiziana reports excellent safety profile with intranasal foralumab after 37.4 patient-years cumulative exposureFDA denial of Sanofi’s tolebrutinib for nrSPMS shows need for safe therapy BOSTON, Dec.

Longtime Texas high school football coach Mike Robinson has died, DeSoto coach Claude Mathis confirmed to The Dallas Morning ...

A fully integrated wheelchair drive-control platform, the ASL iON includes Bluetooth connectivity for up to eight devices, multiple active drive controls for the user to navigate through, ...

Although health concerns sidelined Sean Mahoney this fall, the former Marlborough football coach will join his grandson, ...

A new study by the University of Turku and Turku University Hospital, Finland, found that a significant proportion of Parkinson's disease diagnoses are later corrected. Up to one in six diagnoses ...

Teva received Fast Track designation from the U.S. Food and Drug Administration for emrusolmin (TEV-56286), an investigational treatment for Multiple System Atrophy (MSA) in Phase 2 development. New ...

Emrusolmin is expected to improve symptoms of MSA by targeting alpha synuclein oligomers. The Food and Drug Administration (FDA) has granted Fast Track designation to emrusolmin (TEV-56286) for the ...