Background: PHD2-haplodeficient macrophages (MØs) are promising candidates for the treatment of ischemia-related conditions due to their capacity to modulate the ischemic microenvironment. However, ...

高血压肾病（Hypertensive Nephropathy, HN）是慢性高血压引起的进行性肾脏疾病，是全球终末期肾病（ESRD）的主要原因之一。尽管抗高血压药物如血管紧张素转换酶抑制剂（ACEI）和血管紧张素受体阻滞剂（ARB）在控制血压方面取得了显著进展，但部分患者仍会出现 ...

本研究针对骨再生中血管化不足的难题，开发了负载PEI/PHD2 siRNA复合物的PLGA-生物活性玻璃支架。通过沉默缺氧诱导因子HIF-1α的关键负调控因子PHD2，显著增强人脐静脉内皮细胞（HUVEC）的血管生成能力和人乳牙干细胞（SHED）的成骨分化。该双功能支架为颅颌面骨 ...

In this valuable study, Taber et al. used a battery of biophysical and structural approaches to characterize the impact of erythrocytosis-related mutations in prolyl hydroxylase domain protein 2 (PHD2 ...

本研究首次揭示抗缺血药物曲美他嗪（TMZ）通过调控PHD2/HIF-1α/HO-1信号轴改善高血压肾病（HN）的新机制。实验表明TMZ能下调 ...

Community driven content discussing all aspects of software development from DevOps to design patterns. Git isn’t hard to learn. Moreover, with a Git GUI such as Atlassian’s Sourcetree, and a SaaS ...

Windows 11 is available for download worldwide. Microsoft has released it as a free upgrade, which means you do not need to pay to upgrade your computer to Windows 11. It is available for free ...

Want to boot your Raspberry Pi from USB instead of unreliable SD cards? If you've used a Raspberry Pi long enough, you've probably faced the… ...

自 PHD2 首次搭载英伟达 GB200 超级计算机以来，这款行业首款 224Gbps 背板解决方案便迅速成为 AI 硬件的黄金标准。在 GTC 2025 ...