The 49ers have arguably the toughest two-game closing stretch among the teams in playoff positions. They face the Chicago ...

San Francisco already clinched a playoff berth but finds itself in the thick of the NFC West and wild card races.

Philip Rivers, the grandfather and former Pro Football Hall of Fame semifinalist, came out of retirement to play for the ...

Three more teams are playoff-bound after Monday's contest between the San Francisco 49ers and the Indianapolis Colts.

With the win, the 49ers moved into second place in the NFC West and fifth place in the conference standings. They hold the division record tiebreaker over the Los Angeles Rams. Both teams are a game ...

The Indianapolis Colts lose to the San Francisco 49ers in NFL Week 16 action on 'Monday Night Football': Score updates, highlights ...

The Week 16 edition of "Monday Night Football" between the Indianapolis Colts (8-7) and the San Francisco 49ers (11-4) will ...

As a result of the Indianapolis Colts losing their Week 16 matchup with the San Francisco 49ers on Monday Night Football, the ...

Brock Purdy was a vastly different quarterback on Monday night against the Colts compared to his prior Monday Night Football ...

The Buffalo Bills, Jacksonville Jaguars and Los Angeles Chargers have qualified for the AFC playoffs with the Indianapolis ...

The Jacksonville Jaguars will have a chance at winning the Super Bowl this season after earning a playoff spot following ...

The San Francisco 49ers have beaten the Indianapolis Colts 48-27 on “Monday Night Football” behind Brock Purdy ’s career-high five touchdown passes. Christian McCaffrey racked up 146 total scrimmage ...