The San Francisco 49ers still have a chance to claim the one seed in the NFC playoff bracket with a win in Week 16 over the ...

The Indianapolis Colts are looking to snap a four-game losing streak and get back into the AFC playoff picture Monday night.

The Sporting News is tracking live scoring updates and highlights for 49ers vs. Colts on "Monday Night Football." Follow for complete results from the NFL Week 16 prime-time game.

The Chargers have won 11 games and are still in the hunt for an AFC West title. That doesn’t mean they are Super Bowl ready ...

The Indianapolis Colts host the San Francisco 49ers on "Monday Night Football": Inactives, injury report, who's in, who's out ...

A pair of teams fighting for the postseason but trending in different directions face off on Monday, Dec. 22 to close Week 16 ...

Philip Rivers and the Indianapolis Colts face Christian McCaffrey and the San Francisco 49ers in Week 16 of the NFL season on Monday Night Football at Lucas Oil Stadium.

The Colts' playoff chances have taken a nosedive along with their record of late: they're on a four-game losing streak after ...

Football fever is running high in the Windy City as the Chicago Bears prepare for their first playoff appearance since the ...

The San Francisco 49ers, on a four-game winning streak, try to stay hot Monday night against an Indianapolis Colts team on a ...

Get the best 49ers vs. Colts predictions and odds ahead of Week 16 Monday Night Football on December 22, 2025. Take the Over.

The San Francisco 49ers, led by quarterback Brock Purdy, face the Indianapolis Colts, led by quarterback Philip Rivers, on ...