49ers thrash Colts behind Purdy’s 5 TD passes: Live updates and reaction from NFL ‘Monday Night Football’

The San Francisco 49ers have beaten the Indianapolis Colts 48-27 on “Monday Night Football” behind Brock Purdy ’s career-high five touchdown passes. Christian McCaffrey racked up 146 total scrimmage yards and caught two touchdowns, while George Kittle made seven receptions for 115 yards and a TD before leaving the game with an ankle injury.

49ers playoff picture: Odds, remaining schedule, NFC West standings

The 49ers have made the postseason again after missing out in 2024. Here's a look at their playoff outlook and remaining schedule.

It's Time to Take the 49ers Seriously As Super Bowl Contenders

Brock Purdy was a vastly different quarterback on Monday night against the Colts compared to his prior Monday Night Football appearance when he threw three inte

NFL predictions: Playoff implications for 49ers vs. Colts on Monday Night Football from proven model

According to SportsLine's Inside the Lines team, Indianapolis on Monday night has much more to lose in Week 16

What are Packers playoff chances after loss to Bears? Odds, scenarios

Can the Packers still make the playoffs after the loss to the Bears? Where Green Bay stands in NFC playoff picture.
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