The San Francisco 49ers beat the Indianapolis Colts 48-27, led by Brock Purdy’s 5 TDs. Colin Cowherd asks if the now 11-4 49ers are serious title contenders.

A dominant win reshapes belief inside the San Francisco 49ers, as a left tackle explains why the quarterback’s poise is driving a late-season surge.

Brock Purdy had plenty of respect after sharing the field with 44-year-old Philip Rivers on Monday night. The San Francisco quarterback outdueled the veteran in a 48-27 road win over the Indianapolis Colts,

49ers insider David Lombardi would look into Purdy's outing against Indianapolis and how efficient he has been, posting a graph that has his quarterback efficiency vastly better than anybody in the league in 2025, while calling out the star's detractors.

After 49ers starting QB Brock Purdy suffered turf toe in his right foot in a 17-13 Week 1 win over the Seattle Seahawks, backup QB Mac Jones replaced him. Purdy would return in a 26-21 Week 4 loss to the Jacksonville Jaguars but reaggravated the injury, missing six more games.

Brock Purdy and the San Francisco 49ers earned a statement 48–27 road win over Philip Rivers and the Indianapolis Colts on Monday Night Football, as both quarterbacks put on an entertaining aerial showcase.

Brock Purdy praised Kyle Shanahan’s play-calling after throwing a career-high five touchdowns on Monday Night Football.