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Day 9 🧪 Welcome back to 30 Days of ASCP: Make It Make Sense, because once you get it, you never forget it. Elution and adsorption are both used to separate antibodies from red blood cells, but they serve different purposes. Elution is used when an antibody is already attached to the patient’s red cells; we strip it off to identify what that antibody is, which is especially important in cases like positive DATs or hemolytic disease of the newborn. Adsorption is used when antibodies are free in t

Day 7 🧪 Welcome back to 30 Days of ASCP: Make It Make Sense because once you get it, you never forget it. DIC, TTP, and HUS all cause low platelets and hemolytic anemia, but the why behind each one is completely different. DIC is widespread clotting and bleeding at the same time; clotting factors get used up everywhere. TTP is driven by a lack of ADAMTS13, causing large vWF clots that shear RBCs and drop platelets. HUS is similar to TTP but classically follows a shiga-toxin E. coli infection an

Day 9 🧪 Welcome to 30 Days of ASCP: Ratchet Study Tips🤪🤏🏽🤏🏽🤏🏽 Today we’re finally clearing up reactive lymphocytes vs monocytes: the cells everybody loves to mix up on diff counts. The secret is chromatin first: reactive lymphs usually have fine chromatin and may show a visible nucleolus(especially immunoblasts), but not all reactive lymphs will have one, so don’t rely on that alone. They often have light to pale blue cytoplasm that hugs surrounding RBCs. Monocytes do not have nucleoli,

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