As a pharmacist, Three reasons why I prefer recommending D- Mannose for UTI prevention VS Cranberry Juice! Never heard of D- Mannose? It’s a natural sugar that is found in fruits and vegetables that does not absorb into the body but allows bacteria to adhere to it and then can be flushed out as opposed to sticking to the bladder wall to cause a UTI. 1. It is very effective and I’ve read numerous studies sharing the effectiveness of D- Mannose for UTI prevention even for women with reduced estrog